A few weeks ago, we spoke with one of the world’s leading experts on the 5-HT2A receptor, Ryan Gumpper. As psychedelic drug development matures, the 5-HT2A receptor remains a central node in the field, not only for classical psychedelics, but increasingly for the next generation of neuroplastogens. We discuss how new research is refining our understanding of the 5-HT2AR, why it continues to anchor much of the therapeutic promise in psychedelic science, as well as how polypharmacology beyond the 5-HT2AR may shape the next generation of therapeutics. Conducted as part of Cascades Analytics’ conference coverage, in partnership with Arrowhead SciTech Conferences & Events.